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T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Endothelin 1 (ET-1), mainly produced from vascular endothelial cells, induces vasoconstriction in physiological conditions. The endothelin receptor antagonist is among the most effective agents for pulmonary hypertension. However, little is known about the production source of ET-1 in inflammation a...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Shinagawa, Shoshi, Okazaki, Takahiro, Ikeda, Mari, Yudoh, Kazuo, Kisanuki, Yaz Y., Yanagisawa, Masashi, Kawahata, Kimito, Ozaki, Shoichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670167/
https://ncbi.nlm.nih.gov/pubmed/29101349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14202-5
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