T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Endothelin 1 (ET-1), mainly produced from vascular endothelial cells, induces vasoconstriction in physiological conditions. The endothelin receptor antagonist is among the most effective agents for pulmonary hypertension. However, little is known about the production source of ET-1 in inflammation a...

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Vydáno v:Sci Rep
Hlavní autoři: Shinagawa, Shoshi, Okazaki, Takahiro, Ikeda, Mari, Yudoh, Kazuo, Kisanuki, Yaz Y., Yanagisawa, Masashi, Kawahata, Kimito, Ozaki, Shoichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670167/
https://ncbi.nlm.nih.gov/pubmed/29101349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14202-5
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