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Tonic Signals: Why do Lymphocytes Bother?

Since the 1990s it has been known that B- and T- lymphocytes exhibit low-level, constitutive signaling in the basal state (“tonic signaling”). These lymphocytes display a range of affinity for self, which generates a scale of tonic signaling. Surprisingly, what signaling pathways are active in the b...

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Veröffentlicht in:Trends Immunol
Hauptverfasser: Myers, Darienne R., Zikherman, Julie, Roose, Jeroen P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669999/
https://ncbi.nlm.nih.gov/pubmed/28754596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2017.06.010
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