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HDAC inhibitors enhance the immunotherapy response of melanoma cells

We focused on the ability of the pan-histone deacetylase (HDAC) inhibitors AR42 and sodium valproate to alter the immunogenicity of melanoma cells. Treatment of melanoma cells with HDAC inhibitors rapidly reduced the expression of multiple HDAC proteins as well as the levels of PD-L1, PD-L2 and ODC,...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Booth, Laurence, Roberts, Jane L., Poklepovic, Andrew, Kirkwood, John, Dent, Paul
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669957/
https://ncbi.nlm.nih.gov/pubmed/29137331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17950
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