Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

Utilizing the TCGA PANCAN12 dataset we discovered that cancer patients with mutations in TP53 tumor suppressor and overexpression of MDM2 oncogene exhibited decreased survival post treatment. Interestingly, in the case of breast cancer patients, this phenomenon correlated with high expression level...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tracz-Gaszewska, Zuzanna, Klimczak, Marta, Biecek, Przemyslaw, Herok, Marcin, Kosinski, Marcin, Olszewski, Maciej B., Czerwińska, Patrycja, Wiech, Milena, Wiznerowicz, Maciej, Zylicz, Alicja, Zylicz, Maciej, Wawrzynow, Bartosz
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669876/
https://ncbi.nlm.nih.gov/pubmed/29137250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18899
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