Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia

Esophageal squamous cell carcinoma (ESCC) in humans is a deadly disease associated with dietary zinc (Zn)-deficiency. In the rat esophagus, Zn-deficiency induces cell proliferation, alters mRNA and microRNA gene expression, and promotes ESCC. We investigated whether Zn-deficiency alters cell metabol...

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Vydáno v:Oncotarget
Hlavní autoři: Fong, Louise Y., Jing, Ruiyan, Smalley, Karl J., Taccioli, Cristian, Fahrmann, Johannes, Barupal, Dinesh K., Alder, Hansjuerg, Farber, John L., Fiehn, Oliver, Croce, Carlo M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669858/
https://ncbi.nlm.nih.gov/pubmed/29137232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18434
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