MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency

Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC), and marginal ZD is prevalent in humans. In rats, marked-ZD (3 mg Zn/kg diet) induces a proliferative esophagus with a 5-microRNA signature (miR-31, -223, -21, -146b, -146a) and promotes ESCC. Here we report that mo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fong, Louise Y., Taccioli, Cristian, Jing, Ruiyan, Smalley, Karl J., Alder, Hansjuerg, Jiang, Yubao, Fadda, Paolo, Farber, John L., Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905434/
https://ncbi.nlm.nih.gov/pubmed/26918602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7561
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