MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency

Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC), and marginal ZD is prevalent in humans. In rats, marked-ZD (3 mg Zn/kg diet) induces a proliferative esophagus with a 5-microRNA signature (miR-31, -223, -21, -146b, -146a) and promotes ESCC. Here we report that mo...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Fong, Louise Y., Taccioli, Cristian, Jing, Ruiyan, Smalley, Karl J., Alder, Hansjuerg, Jiang, Yubao, Fadda, Paolo, Farber, John L., Croce, Carlo M.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Priority Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905434/
https://ncbi.nlm.nih.gov/pubmed/26918602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7561
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