Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression

Zinc (Zn)-deficiency (ZD) is implicated in the pathogenesis of human oral-esophageal cancers. Previously, we showed that in ZD mice genetic deletion of cyclooxygenase-2 (Cox-2) enhances N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. By contrast, Cox-2 deletion offers protection in Zn...

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Detalhes bibliográficos
Main Authors: Wan, Shao-Gui, Taccioli, Cristian, Jiang, Yubao, Chen, Hongping, Smalley, Karl J, Huang, Kun, Liu, Xiu-Ping, Farber, John L, Croce, Carlo M, Fong, Louise Y Y
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Cancer Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015018/
https://ncbi.nlm.nih.gov/pubmed/20857495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25688
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