Epiregulin and EGFR interactions are involved in pain processing

The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth, proliferation, and tissue regeneration. In the present study, we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG),...

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Publicat a:J Clin Invest
Autors principals: Martin, Loren J., Smith, Shad B., Khoutorsky, Arkady, Magnussen, Claire A., Samoshkin, Alexander, Sorge, Robert E., Cho, Chulmin, Yosefpour, Noosha, Sivaselvachandran, Sivaani, Tohyama, Sarasa, Cole, Tiffany, Khuong, Thang M., Mir, Ellen, Gibson, Dustin G., Wieskopf, Jeffrey S., Sotocinal, Susana G., Austin, Jean Sebastien, Meloto, Carolina B., Gitt, Joseph H., Gkogkas, Christos, Sonenberg, Nahum, Greenspan, Joel D., Fillingim, Roger B., Ohrbach, Richard, Slade, Gary D., Knott, Charles, Dubner, Ronald, Nackley, Andrea G., Ribeiro-da-Silva, Alfredo, Neely, G. Gregory, Maixner, William, Zaykin, Dmitri V., Mogil, Jeffrey S., Diatchenko, Luda
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669538/
https://ncbi.nlm.nih.gov/pubmed/28783046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87406
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