Epiregulin and EGFR interactions are involved in pain processing

The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth, proliferation, and tissue regeneration. In the present study, we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG),...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Martin, Loren J., Smith, Shad B., Khoutorsky, Arkady, Magnussen, Claire A., Samoshkin, Alexander, Sorge, Robert E., Cho, Chulmin, Yosefpour, Noosha, Sivaselvachandran, Sivaani, Tohyama, Sarasa, Cole, Tiffany, Khuong, Thang M., Mir, Ellen, Gibson, Dustin G., Wieskopf, Jeffrey S., Sotocinal, Susana G., Austin, Jean Sebastien, Meloto, Carolina B., Gitt, Joseph H., Gkogkas, Christos, Sonenberg, Nahum, Greenspan, Joel D., Fillingim, Roger B., Ohrbach, Richard, Slade, Gary D., Knott, Charles, Dubner, Ronald, Nackley, Andrea G., Ribeiro-da-Silva, Alfredo, Neely, G. Gregory, Maixner, William, Zaykin, Dmitri V., Mogil, Jeffrey S., Diatchenko, Luda
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669538/
https://ncbi.nlm.nih.gov/pubmed/28783046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87406
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