Epiregulin and EGFR interactions are involved in pain processing

The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth, proliferation, and tissue regeneration. In the present study, we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG),...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Martin, Loren J., Smith, Shad B., Khoutorsky, Arkady, Magnussen, Claire A., Samoshkin, Alexander, Sorge, Robert E., Cho, Chulmin, Yosefpour, Noosha, Sivaselvachandran, Sivaani, Tohyama, Sarasa, Cole, Tiffany, Khuong, Thang M., Mir, Ellen, Gibson, Dustin G., Wieskopf, Jeffrey S., Sotocinal, Susana G., Austin, Jean Sebastien, Meloto, Carolina B., Gitt, Joseph H., Gkogkas, Christos, Sonenberg, Nahum, Greenspan, Joel D., Fillingim, Roger B., Ohrbach, Richard, Slade, Gary D., Knott, Charles, Dubner, Ronald, Nackley, Andrea G., Ribeiro-da-Silva, Alfredo, Neely, G. Gregory, Maixner, William, Zaykin, Dmitri V., Mogil, Jeffrey S., Diatchenko, Luda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669538/
https://ncbi.nlm.nih.gov/pubmed/28783046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87406
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