Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth

Guanosine monophosphate synthetase (GMPS), encoded by guaA gene, is a key enzyme for guanine nucleotide biosynthesis in Mycobacterium tuberculosis. The guaA gene from several bacterial pathogens has been shown to be involved in virulence; however, no information about the physiological effect of dir...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Biochem Biophys Rep
Autores principales: Villela, Anne Drumond, Eichler, Paula, Pinto, Antonio Frederico Michel, Rodrigues-Junior, Valnês, Yates III, John R., Bizarro, Cristiano Valim, Basso, Luiz Augusto, Santos, Diógenes Santiago
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669397/
https://ncbi.nlm.nih.gov/pubmed/29124214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.10.005
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares