Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M. tuberculosis knockout strain for cdd gene was obtained by allelic replacement. Evaluatio...

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Библиографические подробности
Опубликовано в: :Mem Inst Oswaldo Cruz
Главные авторы: Villela, Anne Drumond, Rodrigues-Junior, Valnês S, Pinto, Antônio Frederico Michel, Falcão, Virgínia Carla de Almeida, Sánchez-Quitian, Zilpa Adriana, Eichler, Paula, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Santos, Diógenes Santiago
Формат: Artigo
Язык:Inglês
Опубликовано: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Предметы:
Short Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661903/
https://ncbi.nlm.nih.gov/pubmed/29091140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760170105
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