Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth

Guanosine monophosphate synthetase (GMPS), encoded by guaA gene, is a key enzyme for guanine nucleotide biosynthesis in Mycobacterium tuberculosis. The guaA gene from several bacterial pathogens has been shown to be involved in virulence; however, no information about the physiological effect of dir...

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Bibliographic Details
Published in:Biochem Biophys Rep
Main Authors: Villela, Anne Drumond, Eichler, Paula, Pinto, Antonio Frederico Michel, Rodrigues-Junior, Valnês, Yates III, John R., Bizarro, Cristiano Valim, Basso, Luiz Augusto, Santos, Diógenes Santiago
Format: Artigo
Language:Inglês
Published: Elsevier 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669397/
https://ncbi.nlm.nih.gov/pubmed/29124214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.10.005
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