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Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain

In a recent clinical trial, the drug BIA 10-2474, a putative fatty acid amide hydrolase(FAAH) inhibitor, was responsible for severe adverse events (SAEs), including one death. To date, there has been little reliable information divulged about the potency of BIA 10-2474 at FAAH in the central nervous...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Tong, Junchao, Mizrahi, Romina, Houle, Sylvain, Kish, Stephen J, Boileau, Isabelle, Nobrega, Jose, Rusjan, Pablo M, Wilson, Alan A
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669339/
https://ncbi.nlm.nih.gov/pubmed/27650910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16668890
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