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Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain

In a recent clinical trial, the drug BIA 10-2474, a putative fatty acid amide hydrolase(FAAH) inhibitor, was responsible for severe adverse events (SAEs), including one death. To date, there has been little reliable information divulged about the potency of BIA 10-2474 at FAAH in the central nervous...

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Bibliografische gegevens
Gepubliceerd in:J Cereb Blood Flow Metab
Hoofdauteurs: Tong, Junchao, Mizrahi, Romina, Houle, Sylvain, Kish, Stephen J, Boileau, Isabelle, Nobrega, Jose, Rusjan, Pablo M, Wilson, Alan A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: SAGE Publications 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669339/
https://ncbi.nlm.nih.gov/pubmed/27650910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16668890
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