Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain

In a recent clinical trial, the drug BIA 10-2474, a putative fatty acid amide hydrolase(FAAH) inhibitor, was responsible for severe adverse events (SAEs), including one death. To date, there has been little reliable information divulged about the potency of BIA 10-2474 at FAAH in the central nervous...

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Bibliografske podrobnosti
izdano v:J Cereb Blood Flow Metab
Main Authors: Tong, Junchao, Mizrahi, Romina, Houle, Sylvain, Kish, Stephen J, Boileau, Isabelle, Nobrega, Jose, Rusjan, Pablo M, Wilson, Alan A
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2016
Teme:
Brief Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669339/
https://ncbi.nlm.nih.gov/pubmed/27650910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16668890
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