The polyglutamine-expanded androgen receptor has increased DNA binding and reduced transcriptional activity

Expansion of a polyglutamine-encoding trinucleotide CAG repeat in the androgen receptor (AR) to more than 37 repeats is responsible for the X-linked neuromuscular disease spinal and bulbar muscular atrophy (SBMA). Here we evaluated the effect of polyglutamine length on AR function in Xenopus oocytes...

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Vydáno v:Biochem Biophys Rep
Hlavní autoři: Belikov, Sergey, Bott, Laura C., Fischbeck, Kenneth H., Wrange, Örjan
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668691/
https://ncbi.nlm.nih.gov/pubmed/29124176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.07.014
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