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The polyglutamine-expanded androgen receptor has increased DNA binding and reduced transcriptional activity
Expansion of a polyglutamine-encoding trinucleotide CAG repeat in the androgen receptor (AR) to more than 37 repeats is responsible for the X-linked neuromuscular disease spinal and bulbar muscular atrophy (SBMA). Here we evaluated the effect of polyglutamine length on AR function in Xenopus oocytes...
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| Veröffentlicht in: | Biochem Biophys Rep |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5668691/ https://ncbi.nlm.nih.gov/pubmed/29124176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2015.07.014 |
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