EGFR Mutations Compromise Hypoxia-associated Radiation Resistance Through Impaired Replication Fork-associated DNA Damage Repair

Epidermal growth factor receptor (EGFR) signaling has been implicated in hypoxia-associated resistance to radiation or chemotherapy. Non-small cell lung carcinomas (NSCLC) with activating L858R or ΔE746–E750 EGFR mutations exhibit elevated EGFR activity and downstream signaling. Here, relative to wi...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Saki, Mohammad, Makino, Haruhiko, Javvadi, Prashanthi, Tomimatsu, Nozomi, Ding, Liang-Hao, Clark, Jennifer E., Gavin, Elaine, Takeda, Kenichi, Andrews, Joel, Saha, Debabrata, Story, Michael D., Burma, Sandeep, Nirodi, Chaitanya S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668182/
https://ncbi.nlm.nih.gov/pubmed/28801308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0136
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