Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation

Rapidly proliferating cells increase glycolysis at the expense of oxidative phosphorylation (oxphos) to generate sufficient levels of glycolytic intermediates for use as anabolic substrates. The pyruvate dehydrogenase complex (PDC) is a critical mitochondrial enzyme that catalyzes pyruvate’s convers...

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Udgivet i:Cancer Res
Main Authors: Jackson, Laura E., Kulkarni, Sucheta, Wang, Huabo, Lu, Jie, Dolezal, James M., Bharathi, Sivakama S., Ranganathan, Sarangarajan, Patel, Mulchand S., Deshpande, Rahul, Alencastro, Frances, Wendell, Stacy G., Goetzman, Eric S., Duncan, Andrew W., Prochownik, Edward V.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668145/
https://ncbi.nlm.nih.gov/pubmed/28883002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1325
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