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Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis

The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-fucosyltransferase1 (Pofut1), which transfers...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ajima, Rieko, Suzuki, Emiko, Saga, Yumiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667770/
https://ncbi.nlm.nih.gov/pubmed/29095923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187248
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