Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma

We synthesized a novel aryl-guanidino compound, DCZ3301, and found that it has potent cytotoxicity against multiple human cancer cell lines. The anticancer activity was most potent against multiple myeloma (MM). DCZ3301 induced cytotoxicity in MM cell lines, as well as patient myeloma cells, in part...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Gao, Minjie, Li, Bo, Sun, Xi, Zhou, Yunfei, Wang, Yingcong, Tompkins, Van S., Xu, Zhijian, Indima, Nekitsing, Wang, Houcai, Xiao, Wenqin, Gao, Lu, Chen, Gege, Wu, Huiqun, Wu, Xiaosong, Kong, Yuanyuan, Xie, Bingqian, Zhang, Yiwen, Chang, Gaomei, Hu, Liangning, Yang, Guang, Dai, Bojie, Tao, Yi, Zhu, Weiliang, Shi, Jumei
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667341/
https://ncbi.nlm.nih.gov/pubmed/29109769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.18345
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