DCZ0814 induces apoptosis and G0/G1 phase cell cycle arrest in myeloma by dual inhibition of mTORC1/2

Purpose: The present study investigates the effect of DCZ0814 in multiple myeloma (MM) cells, and determines the molecular mechanism of its antitumor activity against MM. Methods: The effects of DCZ0814 were evaluated in vitro using human MM cell lines (ARP1 and OCI-MY5) and in vivo in a murine xeno...

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Publicado en:Cancer Manag Res
Autores principales: Kong, Yuanyuan, Li, Bo, Chang, Shuaikang, Gao, Lu, Xu, Zhijian, He, Wan, Yang, Guang, Xie, Bingqian, Chen, Gege, Hu, Liangning, Lu, Kang, Wang, Yingcong, Wu, Xiaosong, Zhu, Weiliang, Shi, Jumei
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove 2019
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549748/
https://ncbi.nlm.nih.gov/pubmed/31213901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S194202
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