Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma

We synthesized a novel aryl-guanidino compound, DCZ3301, and found that it has potent cytotoxicity against multiple human cancer cell lines. The anticancer activity was most potent against multiple myeloma (MM). DCZ3301 induced cytotoxicity in MM cell lines, as well as patient myeloma cells, in part...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Gao, Minjie, Li, Bo, Sun, Xi, Zhou, Yunfei, Wang, Yingcong, Tompkins, Van S., Xu, Zhijian, Indima, Nekitsing, Wang, Houcai, Xiao, Wenqin, Gao, Lu, Chen, Gege, Wu, Huiqun, Wu, Xiaosong, Kong, Yuanyuan, Xie, Bingqian, Zhang, Yiwen, Chang, Gaomei, Hu, Liangning, Yang, Guang, Dai, Bojie, Tao, Yi, Zhu, Weiliang, Shi, Jumei
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667341/
https://ncbi.nlm.nih.gov/pubmed/29109769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.18345
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