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Blocking of the Ubiquitin-Proteasome System Prevents Inflammation-Induced Bone Loss by Accelerating M-CSF Receptor c-Fms Degradation in Osteoclast Differentiation

Anti-osteoporotic activity of a blocker of the ubiquitin-proteasome system, bortezomib, has known to be achieved by directly opposed action in increased bone formation by osteoblasts and in decreased bone destruction by osteoclasts. However, the mechanisms underlying the proteasome blocker inhibitio...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Lee, Kyunghee, Kim, Mi Yeong, Ahn, Heejin, Kim, Han-Sung, Shin, Hong-In, Jeong, Daewon
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666736/
https://ncbi.nlm.nih.gov/pubmed/28946669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18102054
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