Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer

Radioimmunotherapy of solid tumors using antibody-targeted radionuclides has been limited by low therapeutic indices (TIs). We recently reported a novel 3-step pretargeted radioimmunotherapy (PRIT) strategy based on a glycoprotein A33 (GPA33)–targeting bispecific antibody and a small-molecule radioa...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Cheal, Sarah M., Fung, Edward K., Patel, Mitesh, Xu, Hong, Guo, Hong-fen, Zanzonico, Pat B., Monette, Sebastien, Wittrup, K. Dane, Cheung, Nai-Kong V., Larson, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666642/
https://ncbi.nlm.nih.gov/pubmed/28705917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.193250
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