Bone morphogenetic protein and retinoic acid synergistically specify female germ‐cell fate in mice

The mechanism for sex determination in mammalian germ cells remains unclear. Here, we reconstitute the female sex determination in mouse germ cells in vitro under a defined condition without the use of gonadal somatic cells. We show that retinoic acid (RA) and its key effector, STRA8, are not suffic...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Miyauchi, Hidetaka, Ohta, Hiroshi, Nagaoka, So, Nakaki, Fumio, Sasaki, Kotaro, Hayashi, Katsuhiko, Yabuta, Yukihiro, Nakamura, Tomonori, Yamamoto, Takuya, Saitou, Mitinori
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666620/
https://ncbi.nlm.nih.gov/pubmed/28928204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796875
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