In vitro expansion of mouse primordial germ cell‐like cells recapitulates an epigenetic blank slate

The expansion of primordial germ cells (PGCs), the precursors for the oocytes and spermatozoa, is a key challenge in reproductive biology/medicine. Using a chemical screening exploiting PGC‐like cells (PGCLCs) induced from mouse embryonic stem cells (ESCs), we here identify key signaling pathways cr...

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Udgivet i:EMBO J
Main Authors: Ohta, Hiroshi, Kurimoto, Kazuki, Okamoto, Ikuhiro, Nakamura, Tomonori, Yabuta, Yukihiro, Miyauchi, Hidetaka, Yamamoto, Takuya, Okuno, Yukiko, Hagiwara, Masatoshi, Shirane, Kenjiro, Sasaki, Hiroyuki, Saitou, Mitinori
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494472/
https://ncbi.nlm.nih.gov/pubmed/28559416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695862
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