UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing

The Hh pathway controls many morphogenetic processes in metazoans and plays important roles in numerous pathologies and in cancer. Hh signaling is mediated by the activity of the Gli/Ci family of transcription factors. Several studies in Drosophila have shown that ubiquitination by the ubiquitin E3...

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Vydáno v:EMBO Rep
Hlavní autoři: Pan, Chenyu, Xiong, Yue, Lv, Xiangdong, Xia, Yuanxin, Zhang, Shuo, Chen, Hao, Fan, Jialin, Wu, Wenqing, Liu, Feng, Wu, Hailong, Zhou, Zhaocai, Zhang, Lei, Zhao, Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666607/
https://ncbi.nlm.nih.gov/pubmed/28887318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643289
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