Fremanezumab—A Humanized Monoclonal Anti-CGRP Antibody—Inhibits Thinly Myelinated (Aδ) But Not Unmyelinated (C) Meningeal Nociceptors

Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary afferent sensory neurons, is strongly implicated in the pathophysiology of migraine headache, but its role in migraine is still equivocal. As a new approach to migraine treatment, humanized anti-CGRP monoclonal antibod...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Melo-Carrillo, Agustin, Strassman, Andrew M., Nir, Rony-Reuven, Schain, Aaron J., Noseda, Rodrigo, Stratton, Jennifer, Burstein, Rami
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666582/
https://ncbi.nlm.nih.gov/pubmed/28972120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2211-17.2017
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