Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier

BACKGROUND: The presence of calcitonin gene-related peptide and its receptors in multiple brain areas and peripheral tissues previously implicated in migraine initiation and its many associated symptoms raises the possibility that humanized monoclonal anti-calcitonin gene-related peptide antibodies...

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Bibliographische Detailangaben
Veröffentlicht in:Cephalalgia
Hauptverfasser: Noseda, Rodrigo, Schain, Aaron J, Melo-Carrillo, Agustin, Tien, Jason, Stratton, Jennifer, Mai, Fanny, Strassman, Andrew M, Burstein, Rami
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2019
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233263/
https://ncbi.nlm.nih.gov/pubmed/31856583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0333102419896760
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