Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway

Mesangial cell proliferation has been identified as a mainly contributing factor to glomerulosclerosis, which is typical of diabetic nephropathy. However, the specific mechanisms and therapies remain unclear. PDK1 is a critical regulator of cell proliferation, but the specific role of PDK1 in diabet...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Biol Sci
Hauptverfasser: Han, Fei, Xue, Mei, Chang, Yunpeng, Li, Xiaoyu, Yang, Yang, Sun, Bei, Chen, Liming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666525/
https://ncbi.nlm.nih.gov/pubmed/29104493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.20485
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