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Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

Fibrosis is the major pathological feature of diabetic kidney disease (DKD). Autophagy, a process to maintain metabolic homeostasis, is obviously inhibited in DKD. Triptolide (TP) is a traditional Chinese medicine extract known for immune suppression and anti-inflammatory and anti-cancer activities....

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Detalhes bibliográficos
Main Authors: Xiao-yu Li, Shan-shan Wang, Zhe Han, Fei Han, Yun-peng Chang, Yang Yang, Mei Xue, Bei Sun, Li-ming Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-12-01
Colecção:Molecular Therapy: Nucleic Acids
Assuntos:
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2162253117302391
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