Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster

The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for degradation. Mutations in VCP are associated with two neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with Paget's disea...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Genet Genomics
Auteurs principaux: Byrne, Dwayne J., Harmon, Mark J., Simpson, Jeremy C., Blackstone, Craig, O'Sullivan, Niamh C.
Format: Artigo
Langue:Inglês
Publié: Science press ;, Elsevier 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666124/
https://ncbi.nlm.nih.gov/pubmed/29037990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jgg.2017.06.003
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