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Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster
The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for degradation. Mutations in VCP are associated with two neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with Paget's disea...
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| Publicado no: | J Genet Genomics |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Science press ;, Elsevier
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5666124/ https://ncbi.nlm.nih.gov/pubmed/29037990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jgg.2017.06.003 |
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