Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice

Disruption of insulin secretion and clearance both contribute to obesity-induced hyperinsulinemia, though reduced insulin clearance seems to be the main factor. The liver is the major site for insulin degradation, a process mainly coordinated by the insulin-degrading enzyme (IDE). The beneficial eff...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Vettorazzi, Jean Franciesco, Kurauti, Mirian Ayumi, Soares, Gabriela Moreira, Borck, Patricia Cristine, Ferreira, Sandra Mara, Branco, Renato Chaves Souto, Michelone, Luciana de Souza Lima, Boschero, Antonio Carlos, Junior, Jose Maria Costa, Carneiro, Everardo Magalhães
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665899/
https://ncbi.nlm.nih.gov/pubmed/29093479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13974-0
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires