The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation

Recent cell culture and animal studies have suggested that expression of human apo C-III in the liver has a profound impact on the triacylglycerol (TAG)-rich VLDL(1) production under lipid-rich conditions. The apoC-III Gln38Lys variant was identified in subjects of Mexican origin with moderate hyper...

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Pubblicato in:J Lipid Res
Autori principali: Sundaram, Meenakshi, Curtis, Kaitlin R., Amir Alipour, Mohsen, LeBlond, Nicholas D., Margison, Kaitlyn D., Yaworski, Rebecca A., Parks, Robin J., McIntyre, Adam D., Hegele, Robert A., Fullerton, Morgan D., Yao, Zemin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Patient-Oriented and Epidemiological Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665666/
https://ncbi.nlm.nih.gov/pubmed/28887372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M077313
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