Afadin orients cell division to position the tubule lumen in developing renal tubules

In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found that the F-actin-binding protein afadin is required for lumen continuity in developing renal tubules, though its mechanism of action r...

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Veröffentlicht in:Development
Hauptverfasser: Gao, Lei, Yang, Zhufeng, Hiremath, Chitkale, Zimmerman, Susan E., Long, Blake, Brakeman, Paul R., Mostov, Keith E., Bryant, David M., Luby-Phelps, Katherine, Marciano, Denise K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665479/
https://ncbi.nlm.nih.gov/pubmed/28860115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.148908
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