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Optogenetic interrogation of integrin αVβ3 function in endothelial cells

The integrin αVβ3 is reported to promote angiogenesis in some model systems but not in others. Here, we used optogenetics to study the effects of αVβ3 interaction with the intracellular adapter kindlin-2 (Fermt2) on endothelial cell functions potentially relevant to angiogenesis. Because interaction...

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Liao, Zhongji, Kasirer-Friede, Ana, Shattil, Sanford J.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665447/
https://ncbi.nlm.nih.gov/pubmed/28864764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.205203
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