Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumor growth and sensitizes to irinotecan in vivo

The ATP-binding cassette transporter ABCC4 (Multidrug resistance protein 4, MRP4) mRNA level is a strong predictor of poor clinical outcome in neuroblastoma which may relate to its export of endogenous signaling molecules and chemotherapeutic agents. We sought to determine whether ABCC4 contributes...

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Publicat a:Eur J Cancer
Autors principals: Murray, Jayne, Valli, Emanuele, Yu, Denise M.T., Truong, Alan M., Gifford, Andrew J., Eden, Georgina L., Gamble, Laura D., Hanssen, Kimberley M., Flemming, Claudia L., Tan, Alvin, Tivnan, Amanda, Allan, Sophie, Saletta, Federica, Cheung, Leanna, Ruhle, Michelle, Schuetz, John D., Henderson, Michelle J., Byrne, Jennifer A., Norris, Murray D., Haber, Michelle, Fletcher, Jamie I.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665171/
https://ncbi.nlm.nih.gov/pubmed/28735070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2017.06.024
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