Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition

Amplification of the MYCN oncogene occurs in approximately 25% of primary neuroblastomas and is the single most powerful biological marker of poor prognosis in this disease. MYCN transcriptionally regulates a range of biological processes important for cancer, including cell metabolism. The MYCN-reg...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Khan, Aaminah, Valli, Emanuele, Lam, Hayley, Scott, David A., Murray, Jayne, Eden, Georgina, Gamble, Laura D., Pandher, Rupinder, Flemming, Claudia L., Allan, Sophie, Osterman, Andrei L., Haber, Michelle, Norris, Murray D., Fletcher, Jamie I., Yu, Denise M.T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970707/
https://ncbi.nlm.nih.gov/pubmed/32123312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1235-2
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