Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence

Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, the adult stem cells maintain a quiescent state and proliferate upon injury. We show that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state. High-resolution singl...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: de Morrée, Antoine, van Velthoven, Cindy T. J., Gan, Qiang, Salvi, Jayesh S., Klein, Julian D. D., Akimenko, Igor, Quarta, Marco, Biressi, Stefano, Rando, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664522/
https://ncbi.nlm.nih.gov/pubmed/29073096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708725114
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