Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence

Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, the adult stem cells maintain a quiescent state and proliferate upon injury. We show that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state. High-resolution singl...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: de Morrée, Antoine, van Velthoven, Cindy T. J., Gan, Qiang, Salvi, Jayesh S., Klein, Julian D. D., Akimenko, Igor, Quarta, Marco, Biressi, Stefano, Rando, Thomas A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664522/
https://ncbi.nlm.nih.gov/pubmed/29073096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708725114
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