Remote stereoselective deconjugation of α,β-unsaturated esters by simple amidation reactions

The thermodynamically disfavored isomerization of α,β-unsaturated esters to deconjugated β,γ-unsaturated analogues occurs readily when coupled to an amidation. Within the framework of macrocyclic derivatives, it is shown that 15, 16, and 18 membered macrocycles react with tBuOK and anilines to gener...

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Vydáno v:Chem Sci
Hlavní autoři: Vishe, Mahesh, Hrdina, Radim, Poblador-Bahamonde, Amalia I., Besnard, Céline, Guénée, Laure, Bürgi, Thomas, Lacour, Jérôme
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2015
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664367/
https://ncbi.nlm.nih.gov/pubmed/29142723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01118c
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