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Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule
Rac small GTPases and their GEFs of the DOCK family are pivotal checkpoints in development, autoimmunity and bone homeostasis, and their abnormal regulation is associated to diverse pathologies. Small molecules that inhibit their activities are therefore needed to investigate their functions. Here,...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663973/ https://ncbi.nlm.nih.gov/pubmed/29089502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13619-2 |
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