Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells

Imetelstat (GRN163L) is a potent and selective inhibitor of telomerase. We have previously reported that GRN163L could shorten telomeres and limit the lifespan of CD18/HPAF and CAPAN1 pancreatic cancer cells. Here, we examined the effects of GRN163L on two other pancreatic cancer cell lines: AsPC1 a...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Burchett, Katrina M., Etekpo, Asserewou, Batra, Surinder K., Yan, Ying, Ouellette, Michel M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663552/
https://ncbi.nlm.nih.gov/pubmed/29137380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19410
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