TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) were recently found to increase the risk for developing Alzheimer’s disease (AD). In the brain, TREM2 is predominately expressed on microglia, and its association with AD adds to increasing evidence implicatin...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Leyns, Cheryl E. G., Ulrich, Jason D., Finn, Mary B., Stewart, Floy R., Koscal, Lauren J., Remolina Serrano, Javier, Robinson, Grace O., Anderson, Elise, Colonna, Marco, Holtzman, David M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663386/
https://ncbi.nlm.nih.gov/pubmed/29073081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710311114
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