TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) were recently found to increase the risk for developing Alzheimer’s disease (AD). In the brain, TREM2 is predominately expressed on microglia, and its association with AD adds to increasing evidence implicatin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Leyns, Cheryl E. G., Ulrich, Jason D., Finn, Mary B., Stewart, Floy R., Koscal, Lauren J., Remolina Serrano, Javier, Robinson, Grace O., Anderson, Elise, Colonna, Marco, Holtzman, David M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2017
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663386/
https://ncbi.nlm.nih.gov/pubmed/29073081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710311114
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