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Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes
Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The inflammatory kinases IKKε and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation. Here we studied amlexanox, an inhibitor of IKKε/TBK1, i...
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Publicado no: | Cell Metab |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663294/ https://ncbi.nlm.nih.gov/pubmed/28683283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.06.006 |
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