Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes

Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The inflammatory kinases IKKε and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation. Here we studied amlexanox, an inhibitor of IKKε/TBK1, i...

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Vydáno v:Cell Metab
Hlavní autoři: Oral, Elif A., Reilly, Shannon M., Gomez, Andrew V., Meral, Rasimcan, Butz, Laura, Ajluni, Nevin, Chenevert, Thomas L., Korytnaya, Evgenia, Neidert, Adam, Hench, Rita, Rus, Diana, Horowitz, Jeff, Poirier, BreAnne, Zhao, Peng, Lehmann, Kim, Jain, Mohit, Yu, Ruth, Liddle, Christopher, Ahmadian, Maryam, Downes, Michael, Evans, Ronald M., Saltiel, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663294/
https://ncbi.nlm.nih.gov/pubmed/28683283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.06.006
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