Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes

Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The inflammatory kinases IKKε and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation. Here we studied amlexanox, an inhibitor of IKKε/TBK1, i...

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Published in:Cell Metab
Main Authors: Oral, Elif A., Reilly, Shannon M., Gomez, Andrew V., Meral, Rasimcan, Butz, Laura, Ajluni, Nevin, Chenevert, Thomas L., Korytnaya, Evgenia, Neidert, Adam, Hench, Rita, Rus, Diana, Horowitz, Jeff, Poirier, BreAnne, Zhao, Peng, Lehmann, Kim, Jain, Mohit, Yu, Ruth, Liddle, Christopher, Ahmadian, Maryam, Downes, Michael, Evans, Ronald M., Saltiel, Alan R.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663294/
https://ncbi.nlm.nih.gov/pubmed/28683283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.06.006
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