Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway

Isoniazid (INH), a widely used first-line antitubercular drug, has been noted to be associated with hepatotoxicity. In spite of extensive researches over many decades, the mechanism of INH-induced hepatotoxicity still remains poorly understood. Recently, mitochondrial toxicity has been emerging as a...

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Udgivet i:Front Pharmacol
Main Authors: Zhang, Tianguang, Ikejima, Takashi, Li, Lizhong, Wu, Ruiqin, Yuan, Xiaoyan, Zhao, Jun, Wang, Yimei, Peng, Shuangqing
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662931/
https://ncbi.nlm.nih.gov/pubmed/29123480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00753
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