Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

There is a growing body of evidence about the presence and the activity of the miRISC in the nucleus of mammalian cells. Here, we show by quantitative proteomic analysis that Ago2 interacts with the nucleoplasmic protein Sfpq in an RNA-dependent fashion. By a combination of HITS-CLIP and transcripto...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Bottini, Silvia, Hamouda-Tekaya, Nedra, Mategot, Raphael, Zaragosi, Laure-Emmanuelle, Audebert, Stephane, Pisano, Sabrina, Grandjean, Valerie, Mauduit, Claire, Benahmed, Mohamed, Barbry, Pascal, Repetto, Emanuela, Trabucchi, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662751/
https://ncbi.nlm.nih.gov/pubmed/29084942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01126-x
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